Stan Wawrinka is 11/2 to clinch a third grand slam title after beating an emotional Juan Martin del Potro to reach the US Open semi-finals.
Del Potro was bidding to reach his first grand slam semi-final since a wrist injury derailed his career but the Argentinian ran out of steam in Arthur Ashe Stadium as Wawrinka won 7-6 (7/5) 4-6 6-3 6-2.
As Wawrinka prepared to serve for the match, the crowd celebrated Del Potro's revival by singing his name, prompting the tearful 27-year-old to hold up his racket in appreciation.
It is Wawrinka, however, who goes through to the last four and he will now face Kei Nishikori, who had earlier recorded a surprise five-set victory over Andy Murray.
"It was an amazing match for me," Wawrinka, 28/25 to overcome Nishikori, said on court afterwards.
"Even though it was four sets, it was the toughest match mentally and physically against Juan Martin who is an incredible player and I'm really happy to win that match.”
Nishikori, the 2014 finalist, is 15/2 to lift a first grand slam title and 37/50 to reach the final once again.
Wawrinka is now two wins away from a third major crown, to add to the ones he claimed at the Australian Open in 2014 and French Open last year.
In the other semi-final, world number one Novak Djokovic plays France's Gael Monfils.
Djokovic, the 1/8 favourite to retain his us open title, was handed his third walkover in five matches when Jo-Wilfried Tsonga, who was trailing 6-3 6-2, pulled out with a left knee injury.
The Serbian will now face 10th seed and another Frenchman in Monfils, who had earlier beaten compatriot Lucas Pouille 6-4 6-3 6-3.
Monfils is in his first grand slam semi-final since the French Open in 2008 and the 30-year-old is yet to drop a set in this tournament, although he has lost all of his last 12 meetings with Djokovic.
He is 21/4 to end that streak and 10/1 to be crowned champion with odds of 11/4 for him to take the opening set.
“I love watching Gael,” Djokovic said. “He's one of the few players that I will definitely pay a ticket to watch.
“He's very charismatic. Plays with a smile. Enjoys tennis. Enjoys life. But also he seems more focused at this time of his career.
“Especially on the hard court this year maybe he's playing the best tennis he ever played. I'm definitely expecting a tough battle.”